Wednesday, May 6, 2009

I'll eat anything

I may shun religion, but I do believe eternal life is right around the corner. At Sav-On.

Usually, the live-forever theories involve nutritional supplements. Amino acids, wheat grass, melatonin, flavanoids -- been there, swallowed that. The latest miracle is resveratrol, a polyphenolic found in grape skins, peanuts and certain berries. Resveratrol mimics the effects of an almost-starvation diet, and tricks the body into releasing a "survival" gene.

But hold off, they say, resveratrol is very much in the experimental stage. I say, it worked on yeast and worms, so get thee to the pharmacy and don't spare the horses.

Ach, back to the stable. Turns out whether in a supplement or wine, elimination is the big problem. We just pee it out. And scientists won't release it in drug form for another decade if at all.

Which leaves us to try an actual near-starvation diet. Preliminary trials look promising and there are communities of people who have been on the regimen for at least the past few decades with good results (i.e., they're breathing).

It will require self-discipline, an existential leap of faith, and lots of gum. I may have to take up smoking.

And that's not all. When most people sign on to this, starvation is but daily. I have some catching up to do. I'll starve twice a day. Maybe 9 to 12, and part of the afternoon.

34 comments:

  1. Appropos of nothing, I predict you will have 10 comments to "I'll Eat Anything" within the next 8 hours. (Which is roughly quadruple my daily responses.)

    Now I must have some bee pollen with a wheatgrass juice chaser.

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  2. Apropos of not much, have you considered the breatharians?

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  3. I eat dirt imported from Russia. And Valium.

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  4. Oops. I should have said, "apropos adjacent."

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  5. I am pretty sure Resveratrol ended my symptoms of Bipolar disorder. You can read my story on my blog:
    http://glutamateandhealth.wordpress.com/my-story/

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  6. I think I"ll stick with my religion and a healthy slug of wine every day.
    V

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  7. My WV is cress. I don't even need to comment. Just eat that.

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  8. 10:46 CST

    Honey, we may not have a choice.



    "stings"

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  9. I'm partial to tamiflu and relenza boiler makers followed by a good vintage retsyn.

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  10. "Resveratrol" sounds like when you rent a goblin who lives under a bridge.

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  11. Not to be too big of a health nerd here but I have to mention that some of the studies on resveratrol are pretty mindblowing. Big Pharma is pissed that the stuff is natural, it appears to work in its whole and nobody can patent it. I have no doubt they'll isolate something and come up with a drug some day but plain old resveratrol supplements work. Too bad the news is funded primarily by ad revenue from drug companies. The details of these things are always wrapped up in "we aren't sure, drugs aren't available yet" conclusions.

    Okay, now I'm being a leftist anti-corporate nerd, too. I'll stop now.

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  12. Seriously Laurie? I read two articles that said we can't absorb the supplements -- but that isn't true?

    James, the horses!

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  13. I may have some version of this stuff. "Merlot" grape seed moisturizer. Mom got it for me at the Pamona fair. I also have a full tube of Retin-A. Got that (as well as some questionable dental work) by crossing the border.

    I did go to Christain's story. Yes, you can lead me to a link and I will drink. Gotta go, the cats getting ready to hurl

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  14. Fictional WV of the Day: Giddiup










    (hypti)

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  15. I'm confused. What is it supposed to do? So it activates a survival gene. What does that mean? I mean aren't we surviving already just be being alive? Is it supposed to make you live longer? Lose weight? Smell better?

    peakers

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  16. Live long, Margaret. The claims are extensive, including cancer-fighting, stabalize sugar levels, etc. I hadn't heard about Christian's experience, but apparently worked for him.

    and looks like Gary is interested. Anything tastes better than wheatgrass.

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  17. Well, an analogy is in order.

    Remember the good old days when we paid $1.00 for a tank of gas because it was so plentiful? We drove all day and did not think a minute about it. We had muscle cars and lead feet. Then, when gas became scarce and hit $4.00 we all be came interested in how to make our cars more fuel efficient, drove less and slower.

    Well, our body works the same way. When we have limited calories coming in our miticondria, the "engine" of our cells, become more efficient and they slow down. The enzyme that tells them to do this is SIRT1. This was very important when we were hunting and gathering.

    And just like going easy on your car, when your mitocondira go slower they last longer. And as a result, you live longer.

    Now, what resveratrol does is activate SIRT1 even though there is no scarcity of food. Kind of like being energy conscious without regards to the price of fuel.

    The added benefit of Resv is that if it finds cells that are REALLY wasting energy, like cancer cells, it slows them down even more aggressively. Cancer cells get energy from glycolysis and Resv inhibits glycolysis in cells.

    Contrary to popular belief, cancer is not death, in fact it is too much life.

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  18. First, people who eat almost-starvation diets do indeed live longer, on average. But because they are almost starved, they don't have the energy or strength to do much of anything. I'm talking normal, everyday activities here, like taking a walk. That's living?

    Second, I'm not generally a "second pharmaceutical giant on the grassy knoll" kind of guy, but I'll bet Laurie's on to something. So just to be on the safe side, I'm going to have a glass of wine now.

    And you, go eat a sandwich. Seriously.

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  19. Sirits is working on a patentable copycat. They were recently bought by Glaxo for an unreasonable amount of money. They are soon to end a trail for type 2 diabetes and solid tumor inhibition.

    Terry, I do not know where you go your info on peoples energy levels who are on calorie restriction but it is not true. Here is a good example
    http://www.youtube.com/watch?v=P1sVEkYwgsA

    If you have no energy you are not doing it right.

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  20. Interesting stuff. I would add this proviso, my blog is probably not the best place for medical advice. Though red wine is always attractive.

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  21. And even tho his survival gene was de-activated almost 50 years ago, Happy Birthday Gary Cooper.

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  22. I like my thighs the way they are. Plumb and juicy. I'll die tomorrow, happy.

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  23. Sorry. That was some piss poor writing to put on an English Major's blog but I've had more of my quota of the wine this evening.

    "borga"

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  24. I'll dig up some studies if I get a minute. There's a world of studies that never see the light of media attention. (Don't get me started on all the good research about bioidentical plant-based hormones and how all of that has been blunted by big pharma's hold on media outlets -- poor Suzanne Somers is made out to be a fool but she's just the messenger for a lot of researchers whose data is pretty danged compelling.)

    I used to write a lot of materials for doctor groups, HMOs, health insurance companies and even a few of the big online medical advice portals. (Yeah, they hired people like ME to write for them.) It's amazing how much stuff is skewed out there when it comes to this kind of thing.

    I just read day before yesterday that MErck created its own fake peer review-sounding journal to publish favorable stuff about Fosomax. It was on a medical bioethics blog. I tweeted it and don't have the link handy but you KNOW that it's not the only example.

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  25. Didn't you mean "Reverseitall" and please don't start smoking.

    Or maybe it was the WV drug: Zerstsp

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  26. Skoal, Miss H!

    Thanks Laurie, that would be interesting. Now I have to google bioidentical plant hormones, because I've never heard of them.

    Mid-T, you are a clever boy.

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  27. Actually, Christian, even CR proponents say that you not only lose fat, but lose muscle and can even lose bone density, a big concern when it comes to osteoporosis [as much a problem for men as women, by the way]. Reduced strength, stamina and, ahem, libido are also common outcomes. Again, this is living? Tim Tyler, who practices CR himself, outlines its disadvantages here. What first caught my attention about CR, though, and made me run screaming from the room, was this article in New York magazine a few years ago.

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  28. Yes, Terry, I agree to some of the pitfalls of CR, which is why I like Resveratrol as opposed to CR. But worrying about breaking a bone over cancer and disease? Well, take your pick. But remember, I started this post on Resv, not CR.

    There is evidence Resv stops bone loss.
    http://www.liebertonline.com/doi/abs/10.1089/jmf.2005.8.14

    I guess if you want to live fast and die young do what ever you want. But I do not know why people would chose that route when they have people around them that love and depend on them.

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  29. Just to clarify, Christian, even if I were one of those live fast die young types, I'm way behind schedule. I thoroughly plan to be around for a long time, probably to the point of eventually pissing off those who currently love and depend on me. I think I'm totally on schedule for this phase of life. I just tend to look at most extreme diets--or extreme anything, really--with a healthy dose of skepticism. I'm much more an advocate of balance and moderation--including moderation in my moderation. Regarding Resveratrol, I'm all over any good news about that. And I personally love that wine and chocolate and peanut butter and other supposed bad guys are turning out to be good guys.

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  30. I'm still waiting for science to recognize what I hope is the truth contained in Woody Allen's Sleeper: the health benefits of hot fudge sundaes and deep fried foods.

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  31. Warning on Resveratrol: Christian is turning into Benjamin Button...

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  32. I disagree, Anonymous. Christian is not nearly that boring.

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